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KMID : 0370220200640010008
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Yakhak Hoeji
2020 Volume.64 No. 1 p.8 ~ p.20
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Recent Trends in Drug Interaction Studies based on Drug Metabolism
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Lee Jin-Seok
Ahn Sung-Hoon
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Abstract
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In pharmacotherapy, drugs are often taken with other drugs to overcome the disease. Due to an increase in theelderly population and chronic diseases, the combinational co-administering method of drugs is increasing, and theimportance of drug interaction evaluation for drug development and clinical application is also increasing. In the case ofcombination therapy, co-administration of drug may occur drug-drug interactions due to the competition of endogenousproteins such as drug transporter, drug metabolic enzyme, and plasma protein, including direct physicochemical interactionsof drugs. Drug metabolism-based drug interactions are representative of drug-drug interactions in clinical cases. Drugmetabolism mostly occurs in the liver by cytochrome P450s as representative drug metabolic enzymes. In addition, phase2 metabolic enzymes such as glucuronidases and sulfotransferases also have a significant effect on metabolism-based druginteractions. Drug-drug interactions can affect drug efficacy and side effects, and in some cases can be life threatening orcause serious side effects. The combination use of drugs is required to be aware of the potential interactions that mayoccur with co-administration in order to use the drug safely. Therefore, the pharmacist as an expert in medicine must havethe relevant knowledge and ability to cope with problems as needed. In this approach, we introduced the recent researchtrends on drug interactions that can occur based on the metabolism of drugs among these drug interactions, and discussedclinical significance of drug-drug interactions.
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KEYWORD
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Drug-drug interaction, drug metabolism, pharmacokinetics, drug metabolic enzyme
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